NF-κB Is Transported into the Nucleus by Importin α3 and Importin α4
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چکیده
منابع مشابه
Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.
The signal recognition particle (SRP) is a cytoplasmic RNA-protein complex that targets proteins to the rough endoplasmic reticulum. Although SRP functions in the cytoplasm, RNA microinjection and cDNA transfection experiments in animal cells, as well as genetic analyses in yeast, have indicated that SRP assembles in the nucleus. Nonetheless, the mechanisms responsible for nuclear-cytoplasmic t...
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Xeroderma pigmentosum Group A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase. In this study, experiments were carried out to determine the transport mechanisms that are responsible for the UV (ultraviolet)-induced nuclear import of XPA. We found that, in additio...
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The eukaryotic cell nucleoplasm is separated from the cytoplasm by the nuclear envelope. This compartmentation of eukaryotic cells requires that all nuclear proteins must be transported from the cytoplasm into the nucleus. Transport of macromolecules between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs), large protein complexes that penetrate and fuse the nuclear en...
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The vertebrate glucocorticoid receptor (GR) is cytoplasmic without hormone and localizes to the nucleus after hormone binding. GR has two nuclear localization signals (NLS): NL1 is similar in sequence to the SV40 NLS; NL2 is poorly defined, residing in the ligand-binding domain. We found that GR displayed similar hormone-regulated compartmentalization in Saccharomyces cerevisiae and required th...
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1996) and the KNS shuttling domain of the hnRNP K * Zentrum fü r Molekulare Biologie der protein, which allows both import and export (Michael Universitä t Heidelberg et al., 1997). 69120 Heidelberg A fundamental question is how it is possible for the Federal Republic of Germany shuttling transport receptors to carry their cargo in only † Abteilung Molekulare Biologie der Mitose one direction. ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m500814200